Endocrine Abstracts

The local biological activity of the natriuretic peptides ANP, BNP and CNP is regulated by changes in the activity of their guanylyl cyclase (GC)-containing receptors GC-A and GC-B, by the so-called natriuretic peptide clearance receptor NPR-C and by membrane-bound ectoproteases. Activity of GCs is regulated by alterations in the extent of receptor phosphorylation. Dephosphorylation decreases natriuretic peptide-induced GC activity. This mechanism is used for desensitization i...

We present a case of a six year old boy with an enlarging thyroid mass. He was asymptomatic, euthyroid and had no family history of thyroid disease.Examination and neck ultrasound showed hard mass replacing left thyroid lobe with no lymphadenopathy. FNA cytology suggested diagnosis of lymphoepithelial cyst of the thyroid.Left hemithyroidectomy and isthmusectomy was performed. At operation no lymphadenopathy was seen and right thyro...

Previous studies have demonstrated over-expression of cyclooxygenase-2 (COX-2) enzyme and enhanced synthesis of prostanoids, such as prostaglandin E2 (PGE2), in cervical carcinomas. PGE2 mediates its is effects by interacting with one of four receptors termed EP1-4. Expression and signalling of EP receptors, including EP4, are elevated in cervical carcinomas. We have previously proposed that in addition to endogenous PGE2, EP recepto...

GPR83 is an orphan G-protein coupled receptor (GPCR) and is expressed in thymus and brain. Within the brain GPR83 mRNA is identified at high levels in the hypothalamic arcuate nucleus that is known to control for body weight regulation.Expression of GPR83 in the arcuate nucleus and the protection of GPR83 knock-out mice against diet induced obesity prompted us to investigate GPR83 signaling properties as well as potential interaction with the melanocorti...

Objective: The aim of this study was to assess prevalence of impaired awareness of hypoglycaemia (IAH) by the Gold method in people with type 1 diabetes and to compare people with and with IAH regarding metabolic control.Methods: In a cross-sectional study, we assessed IAH in 139 people with type 1 diabetes (54.1y, diabetes duration 24.0y, HbA1c 7.1%) attending the University outpatient department for endocrinology and metabolic diseases. IAH was assesse...

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic disease (Covid-19) has caused millions of deaths worldwide, thus a massive SARS-CoV-2 vaccination campaign has been launched since the end of 2020. Viruses and vaccines can induce adverse thyroid effects; SARS-CoV-2 infection and vaccines have been associated with several thyroid disorders, especially subacute thyroiditis (SAT) and Graves’ disease (GD). We aimed to study the occurrence o...

Background: Craniopharyngiomas (CP) are rare malformational tumors. Clinical presentation and outcome of patients with congenital CP (cCP) are not clear and refer mainly to few case reports in the literature. The aim of this study was to analyze clinical presentation and outcome in patients with cCP.Clinical cases: Seven hundred and nine patients diagnosed with adamantinomatous CP were recruited 1999-2021 in HIT-ENDO, KRANIOPHARYNGEOM 2000 / 2007 / Regis...

Background: Quality of life (QoL) has become a critical component of therapeutic outcomes in the survivors of childhood-onset craniopharyngioma (CP). Visual deficiency adversely affects daily functioning and QoL in childhood CP. This cohort study aimed to report the vision-related QoL in CP patients. Methods: 120 patients with CP were included in this study and prospectively observed. The primary outcome measure was pediatric QoL (PEDQOL score) in patien...

Craniopharyngiomas are rare, embryonic, malformational tumors of the (supra-)sellar region. Due to tumor and/or treatment-related hypothalamic lesions, patients develop morbid obesity. As a major vascular risk factor, obesity leads to reduced 20-year overall survival and a 3- to 19-fold higher cardiovascular mortality after craniopharyngioma compared to the general population. This review studies craniopharyngioma-specific risk factors for vascular damages. Three databases (Pu...

Stereotactic hypothalamotomy in the treatment of morbid sexual deviation was first performed by Prof. Dr. Fritz Roeder 1966 in Univ. Göttingen and installed in University Hamburg-Eppendorf (UKE) by Neuropathologist Dr. Dieter Müller (DM) in the late 1970s. Dr. Dieter Lüdecke (DKL) agreed with Prof. Herrmann, Director of Neurosurgery, to give the Professor position to DM to join the Unit. It was known that the sex behaviour centre in the ventromedial nucleus of C...